Head and Neck Manifestations of Granulomatosis with Polyangiitis (GPA) Mimicking as Carcinoma

Wan Ahmad Amiruddin Wan Hassan, Iylia Ajmal Othman, Azliana Abd Fuaat, Wan Ishlah Leman, Dinsuhaimi Sidek

Abstract


Granulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis mainly affecting the upper airway, ocular, renal and pulmonary systems. Its histopathological hallmark is presence of granulomatous inflammation and presence of circulating anti-neutrophil cytoplasm antibodies (c-ANCA) serologically. Most patients with GPA presented with ENT manifestations as their initial or only presentation. As it can mimic other infectious, allergic, and inflammatory diseases, delay in diagnosis is inevitable. A rapid clinical course of the disease may also mimic malignant disease, leading to misdiagnosis. We are reporting a case of a 52-year-old Malay male, who presented to our center with one month history of progressively worsening nasal blockage associated with blood-stained nasal discharge. His initial diagnosis of nasal septum squamous cell carcinoma was disputed from repeated biopsy. Given the multi-organs involvement of the disease, pathognomonic histopathological findings and C-ANCA positivity, the diagnosis of Granulomatosis with polyangiitis (GPA) was made.

International Journal of Human and Health Sciences Vol. 06 No. 03 July’22 Page: 342-347


Keywords


Granulomatosis with polyangiitis, Wegener’s granulomatosis, Vasculitis, Anti-neutrophil cytoplasm antibodies

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DOI: http://dx.doi.org/10.31344/ijhhs.v6i3.470

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Copyright (c) 2022 Wan Ahmad Amiruddin Wan Hassan, Iylia Ajmal Othman, Azliana Abd. Fuaat, Wan Ishlah Leman, Dinsuhaimi Sidek

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