Association of Admission Glucose Level with Arrythmia and Heart Failure in Hyperglycemic Patients with Non-ST-Segment Elevation Myocardial Infarction

Md Tariqul Islam Khan, Mahmood Hasan Khan, Mariya Tabassum, Mahadi Hassan, SM Tarique Mahmud, Farhana Naznen

Abstract


Background: Observetion of admission blood glucose level in non-ST elevation myocardial infarction is crucial to predict its outcome.

Objective: To find out correlation of plasma glucose level with adverse events like arrythmia and heart failure in hyperglycemic patients with non-STsegment elevation myocardial infarction (NSTEMI).

Methods: This prospective analytical study was conducted in the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh, between June 2016 and May 2017. A total of 130 (95 males and 35 females) patients having NSTEMI participated in the study. Detail history was taken and physical examination was done. Venous blood samples were obtained from all patients to determine their cardiac troponins, plasma blood glucose, HbA1C, lipid profile, serum creatinine, and other cardiac enzymes. Then, the study participants were categorized into two groups. A total of 67 included (44 males and 23 females) in Group I, as having NSTEMI with plasma glucose level 7.8-9.3 mmol/l. In Group II, 63 were included (51 males and 12 females) having NSTEMI with plasma glucose level ≥9.4 mmol/l. Follow up was done according to the standard protocol,i.e. serial ECG, echocardiography, monitoring pulse, blood pressure, and auscultation of the lungs’ base.

Results: The mean age of the patients was 49.68±3.12 years. Incidence of arrhythmia was observed in 4(5.97%) and 20(31.75%) cases in group I and group II respectively, while heart failure was found in 6(8.96%) and 48(76.19%) cases respectively (P<0.001). A statistically significant moderate negative correlation with medium strength of association (r = -0.056) was observed between heart failure (as measured by LVEF and clinical status) and admission plasma glucose levels of the study participants suggesting that the higher was admission plasma glucose level (8.27±1.03 vs. 13.34±3.65; P<0.001),the lower was the LVEF (54.19±7.13 vs. 44.21±7.36; P<0.001), i.e. higher risks of heart failure. Conclusion: A higher admission plasma glucose level relates to a lower LVEF,i.e. higher incidence of arrythmia and heart failure in non ST-elevation MI patients.

International Journal of Human and Health Sciences Vol. 06 No. 03 July’22 Page: 292-297


Keywords


Plasma glucose, arrythmia, heart failure, left ventricular ejection fraction, myocardial infarction

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DOI: http://dx.doi.org/10.31344/ijhhs.v6i3.461

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Copyright (c) 2022 Md Tariqul Islam Khan, Mahmood Hasan Khan, Mariya Tabassum, Mahadi Hassan, SM Tarique Mahmud, Farhana Naznen

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