Correlation Between Age, Body Mass Index, And Blood Selenium Level with Glutathione Peroxidase Activity Among Elderly in South Jakarta

Annisa Nurul Kirana, Erfi Prafiantini, Novi Silvia Hardiany

Abstract


Oxidative stress contributed in aging process and several degenerative diseases. Selenium was an important trace element due to as a component of antioxidants enzymes (selenoproteins), including glutathione peroxidase for protection against free radical.

Objective: We aimed to study the correlation between blood selenium level and plasma glutathione peroxidase activity in elderly.

Materials and Methods: Cross sectional study was held in 5 elderly communities in south Jakarta. Body mass index, blood selenium level and plasma glutathione peroxidase activity were measured in 95 elderly aged between 60-86 years old. Nonparametric correlation was used for correlation analysis.

Results and Discussion: The median of subject’s age was 69 years old (60-86) and for body mass index was 23.57 (13.59-36.05). The median of selenium level among subject was 0.19 (0.023-0.56). The mean of plasma glutathione peroxidase activity was 164.45 U/L ± 68.07. There was no correlation among variables. However, plasma glutathione peroxidase activity decreased with increasing age and body mass index although it was not significant.

Conclusion: There was no correlation between blood selenium level and plasma glutathione peroxidase activity. Detection of plasma selenium level is needed to confirm this result.

International Journal of Human and Health Sciences Vol. 04 No. 02 April’20 Page : 89-93


Keywords


Selenium; Glutathione Peroxidase; Antioxidant; Elderly

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DOI: http://dx.doi.org/10.31344/ijhhs.v4i2.181

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