Evaluation of Serum Uric Acid Levels in Patients with Thyroid Disorders in A Tertiary Care Hospital of Kolkata, India
DOI:
https://doi.org/10.31344/ijhhs.v10i2.938Keywords:
Primary hypothyroidism, primary hyperthyroidism, uric acid, hyperuricemiaAbstract
An analytical, case-control study was conducted in the Department of Biochemistry of R. G. Kar Medical College & Hospital, West Bengal, India, to evaluate changes in serum uric acid levels in patients with thyroid disorders. 50 newly diagnosed cases of primary hypothyroidism and hyperthyroidism in each group, both males and females aged 15-60 years (before starting any kind of thyroid medications) were taken as cases. 50 age and sex matched apparently healthy euthyroid individuals were taken as controls. Our exclusion criteria were: children, older individuals (>60 years), thyroid disorders other than primary hypothyroidism and hyperthyroidism, chronic kidney disease etc. Serum uric acid levels were observed 4.19±0.74 mg/dL, 7.07±1.15 mg/dL, and 4.33±1.01 mg/dL in euthyroid control group, hypothyroid and hyperthyrod patients respectively. Serum uric acid level was found increased in hypothyroid patients as compared to hyperthyroid patients and control individuals. A significant positive correlation was found between serum TSH and uric acid levels in primary hypothyroidism cases (r = +0.765; p<0.05). Besides, a significant negative correlation was observed between serum FT4 and uric acid levels in primary hypothyroidism cases (r = 0.664; p<0.05). Association of serum uric acid with TSH levels in primary hyperthyroid cases did not follow normal distribution pattern; however, it showed statistically non-significant negative correlation (r = 0.223; p>0.05). No differences were observed in serum uric acid levels in cases of primary hyperthyroidism compared to age and sex matched euthyroid controls (p>0.05). However, higher serum uric acid levels were observed in primary hypothyroidism compared to primary hyperthyroidism patients (p<0.05).
International Journal of Human and Health Sciences Vol. 10 No. 02 Apr’26 Page: 116-121
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Copyright (c) 2026 Dipanwita Majumder, Jayanta De, Arindam Sur, Tapobrata Guha Ray
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