A Rare B-Subgroup Causing ABO Discrepancy in Blood Grouping: A Case Report

Authors

  • Rabeya Yousuf Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia
  • Kaalpana Jayakumar Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia
  • Nor Fadzliana Abdullah Thalith Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia
  • Nur Afifah Binti Suhemi Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia
  • Qhasmira Binti Abu Hazir Blood Bank Unit, Department of Diagnostic Laboratory Services, Hospital Canselor Tuanku Muhriz, National University of Malaysia, Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.31344/ijhhs.v8i1.628

Keywords:

B subgroup, ABO discrepancy, Adsorption and elution, anti-H lectin

Abstract

This is a 24-year-old gentleman with underlying status epilepticus, admitted for septic shock secondary to meningoencephalitis. On pretransfusion investigation, his blood grouping showed ABO discrepancy. His forward grouping showed negative reaction with anti-A, and anti-B while his reverse grouping showed strong 3+ reaction with A1 cell and no reaction with B cell. Repeated tests with new samples also showed similar results. Subsequently, test was repeated at room temperature and 4◦C with prolonged incubation and with enzyme treated cells. Forward grouping showed the same result while the reverse grouping showed enhancement with A1 cell (4+). We suspected B subgroup and proceeded with anti-H lectin test which showed 4+ reaction. Adsorption and elution study confirmed the presence of antigen B on patient’s RBCs. Therefore, it is necessary to resolve all discrepancies to ensure safe transfusion practice.

International Journal of Human and Health Sciences Vol. 08 No. 01 Jan’24 Page: 99-102

Downloads

Published

2024-01-21

How to Cite

Yousuf, R., Jayakumar, K., Abdullah Thalith, N. F., Binti Suhemi, N. A., & Abu Hazir, Q. B. (2024). A Rare B-Subgroup Causing ABO Discrepancy in Blood Grouping: A Case Report. International Journal of Human and Health Sciences (IJHHS), 8(1), 99–102. https://doi.org/10.31344/ijhhs.v8i1.628

Issue

Vol. 8 No. 1 (2024)

Section

Case Report

License

Copyright (c) 2024 Rabeya Yousuf, Kaalpana Jayakumar, Nor Fadzliana Abdullah Thalith, Nur Afifah Binti Suhemi, Qhasmira Binti Abu Hazir

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the International Journal of Human and Health Sciences agree to the following terms that:

  1. Authors retain copyright and grant International Journal of Human and Health Sciences the right of first publication of the work.

  2. Creative Commons Licence
    Articles in International Journal of Human and Health Sciences are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.

Most read articles by the same author(s)