Head and Neck Manifestations of Granulomatosis with Polyangiitis (GPA) Mimicking as Carcinoma

Authors

  • Wan Ahmad Amiruddin Wan Hassan Department of Otorhinolaryngology Sultan Ahmad Shah Medical Centre @IIUM 25200 Kuantan Pahang Malaysia
  • Iylia Ajmal Othman Department of Otorhinolaryngology Sultan Ahmad Shah Medical Centre @IIUM 25200 Kuantan Pahang Malaysia
  • Azliana Abd Fuaat Department of Pathology Sultan Ahmad Shah Medical Centre @IIUM 25200 Kuantan, Pahang, Malaysia
  • Wan Ishlah Leman Department of Otorhinolaryngology Sultan Ahmad Shah Medical Centre @IIUM 25200 Kuantan Pahang Malaysia
  • Dinsuhaimi Sidek Department of Otorhinolaryngology Sultan Ahmad Shah Medical Centre @IIUM 25200 Kuantan Pahang Malaysia

DOI:

https://doi.org/10.31344/ijhhs.v6i3.470

Keywords:

Granulomatosis with polyangiitis, Wegener’s granulomatosis, Vasculitis, Anti-neutrophil cytoplasm antibodies

Abstract

Granulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis mainly affecting the upper airway, ocular, renal and pulmonary systems. Its histopathological hallmark is presence of granulomatous inflammation and presence of circulating anti-neutrophil cytoplasm antibodies (c-ANCA) serologically. Most patients with GPA presented with ENT manifestations as their initial or only presentation. As it can mimic other infectious, allergic, and inflammatory diseases, delay in diagnosis is inevitable. A rapid clinical course of the disease may also mimic malignant disease, leading to misdiagnosis. We are reporting a case of a 52-year-old Malay male, who presented to our center with one month history of progressively worsening nasal blockage associated with blood-stained nasal discharge. His initial diagnosis of nasal septum squamous cell carcinoma was disputed from repeated biopsy. Given the multi-organs involvement of the disease, pathognomonic histopathological findings and C-ANCA positivity, the diagnosis of Granulomatosis with polyangiitis (GPA) was made.

International Journal of Human and Health Sciences Vol. 06 No. 03 July’22 Page: 342-347

Downloads

Published

2022-06-13

How to Cite

Wan Hassan, W. A. A., Othman, I. A., Fuaat, A. A., Leman, W. I., & Sidek, D. (2022). Head and Neck Manifestations of Granulomatosis with Polyangiitis (GPA) Mimicking as Carcinoma. International Journal of Human and Health Sciences (IJHHS), 6(3), 342–347. https://doi.org/10.31344/ijhhs.v6i3.470

Issue

Vol. 6 No. 3 (2022)

Section

Case Report

License

Copyright (c) 2022 Wan Ahmad Amiruddin Wan Hassan, Iylia Ajmal Othman, Azliana Abd. Fuaat, Wan Ishlah Leman, Dinsuhaimi Sidek

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in the International Journal of Human and Health Sciences agree to the following terms that:

  1. Authors retain copyright and grant International Journal of Human and Health Sciences the right of first publication of the work.

  2. Creative Commons Licence
    Articles in International Journal of Human and Health Sciences are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.