Evaluation of Liquid Based Cytology (LBC) and Conventional Pap’s Smear Test as Methods of Cervical Cancer Screening

Authors

  • Mehdi Ashik Chowdhury Associate Professor and Head, Department of Pathology, Tairunnessa Memorial Medical College, Gazipur, Bangladesh
  • Asim Ranjan Barua Professor, Department of Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
  • - Asaduzzaman Assistant Professor (Histopathology), Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh
  • Mohammad Mahabubul Hoque Lecturer, Department of Pathology, Sheikh Sayera Khatun Medical College, Gopalganj, Bangladesh
  • DM Arifur Rahman Assistant Professor, Department of Pathology, TMSS Medical College, Bogura, Bangladesh

DOI:

https://doi.org/10.31344/ijhhs.v6i1.374

Keywords:

Liquid Based Cytology, Cervical Cancer Screening

Abstract

Background: Cervical cancer screening can actually prevent most cervical cancers and also facilitates early detection which allows fruitful treatment.

Objective: To evaluate and compare the efficacy of Liquid-based cytology (LBC) with conventional Pap smear test.

Methods: This crosssectional study was conducted between March 2015 and June 2017. A total of 72 women participated in this study attending the Out-Patient Department (OPD) of Gynaecology (Colposcopy Clinic) of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, for VIA test. The smears prepared by the conventional Pap smear method and Liquid-based cytology method were observed by two independent observers in Department of Pathology of the same institution.

Results: The mean age of the patients was 40.22±12.29 years. Considering histopathology as gold standard, in conventional Pap smear preparation our data suggested its sensitivity 87.5%, specificity 92.2%, accuracy 91.7%, positive predictive value 58.3% and negative predictive value 98.3%. In contrast, in Liquid-based cytology, we found its sensitivity 75.0%, specificity 90.6%, accuracy 88.9%, positive predictive value 50.0% and negative predictive value 96.7%.

Conclusion: LBC has practical advantages over conventional preparation by producing monolayer of cells, smaller area to screen, reproducibility and availability of doing adjunct molecular techniques from residual sample. However, conventional preparation shows better sensitivity and positive predictive value and almost similar specificity, negative predictive value and accuracy with LBC.

International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 36-40

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Published

2022-02-07

How to Cite

Chowdhury, M. A., Barua, A. R., Asaduzzaman, .-., Hoque, M. M., & Rahman, D. A. (2022). Evaluation of Liquid Based Cytology (LBC) and Conventional Pap’s Smear Test as Methods of Cervical Cancer Screening. International Journal of Human and Health Sciences (IJHHS), 6(1), 36–40. https://doi.org/10.31344/ijhhs.v6i1.374

Issue

Vol. 6 No. 1 (2022)

Section

Original Articles

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Copyright (c) 2022 Mehdi Ashik Chowdhury, Asim Ranjan Barua, - Asaduzzaman, Mohammad Mahabubul Hoque, DM Arifur Rahman

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