BOSENTAN - endothelin receptor antagonist

Authors

  • Kiran Kumar Singal Professor ,Department of Medicine, M.M.Medical College & Hospital, Kumarhatti, Solan (H.P.)
  • Neerja Singal Professor, Department of Obstetrics and Gynaecology, M.M. Medical College & Hospital, Kumarhatti, Solan (H.P.)
  • Paras Passi Ex.Resident , Department of Medicine, M.M.Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Mohit Singla Assistant Professor, Department of Medicine, M.M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)
  • Nitin Gupta Assistant Professor, Department of Medicine, M.M. Institute of Medical Sciences & Research, Mullana, Ambala(133203)
  • Gautam Sumit Resident, Department of Medicine, M.M. Institute of Medical Sciences & Research, Mullana, Ambala (133203)

DOI:

https://doi.org/10.31344/ijhhs.v3i1.66

Keywords:

Pulmonary Artery Hypertension, Pulmonary Hypertension, bosentan, endothelin receptor antagonist

Abstract

Activation of the endothelin system has been demonstrated in the plasma and lung tissue of PAH (Pulmonary Artery Hypertension) patients. Although it is not clear if the increases in endothelin plasma levels are a cause or a consequence of PH (Pulmonary Hypertension), the data supports a prominent role for the endothelin system in the pathogenesis of PAH. Bosentan is an endothelin receptor antagonist used in the treatment of Primary pulmonary hypertension (PPH) which is a progressive disease with high mortality and administration of the orally active, dual endothelin receptor antagonist bosentan improves exercise endurance, haemodynamics, and functional class over the short term. First-line bosentan therapy was found to improve survival in patients with advanced primary pulmonary hypertension.

International Journal of Human and Health Sciences Vol. 03 No. 01 January’19. Page : 10-13

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Published

2018-11-02

How to Cite

Singal, K. K., Singal, N., Passi, P., Singla, M., Gupta, N., & Sumit, G. (2018). BOSENTAN - endothelin receptor antagonist. International Journal of Human and Health Sciences (IJHHS), 3(1), 10–13. https://doi.org/10.31344/ijhhs.v3i1.66

Issue

Vol. 3 No. 1 (2019)

Section

Review Articles

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