Prophetic Medicine for Treatment of Radiotherapy-Induced Mucositis

Authors

  • Mohd Hafiz Hamzah Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia
  • Irfan Mohamad Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia
  • Nor Shahida Abd Mutalib Department of Otorhinolaryngology-Head & Neck Surgery, Hospital Sultan Abdul Halim, Sungai Petani, Kedah, Malaysia
  • Muhamad Yusri Musa Cluster of Oncology and Radiological Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, Malaysia
  • Siti Azrin Ab Hamid Department of Biostatistics and Research Methodology, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia

DOI:

https://doi.org/10.31344/ijhhs.v6i0.431

Keywords:

propolis mouthwash, mucositis, radiotherapy, nasopharyngeal carcinoma

Abstract

Objective: Mucositis is a debilitating complication of radiotherapy treatment in nasopharyngeal carcinoma (NPC). Mucositis can lead to malnutrition due to poor oral intake, and the cancer treatment protocol might be postponed due to this condition. Until now, there is no specific treatment to prevent radiotherapy-induced mucositis in NPC patients. The usage of propolis mouthwash is believed to be one of the important remedies to reduce the severity of mucositis in the future. We sought to evaluate the effectiveness of propolis mouthwash in preventing radiotherapy-induced mucositis in NPC patients.

Methods: This is a double arm, prospective, randomized control trial (RCT) with intervention involving 17 patients diagnosed with NPC attending ORL-HNS clinic in Institut Perubatan & Pergigian Termaju (IPPT) Bertam. 10 patients were given propolis mouthwash and another 7 patients were given normal saline mouthwash as a placebo. The effectiveness of propolis mouthwash was assessed by repeated measures ANOVA.

Result: All 17 NPC patients were randomly divided into propolis group (intervention) and normal saline group (placebo). 10 patients were given propolis mouthwash and another 7 patients were given normal saline mouthwash. Comparison of adjusted mean and 95% confidence interval of mucositis grading score between propolis mouthwash and normal saline showed at the second week was 0.10(- 0.13, 0.33) vs 1.14(0.31, 1.98), fourth week: 0.50(0.12, 0.88) vs 2.00(1.47, 2.53), and sixth week: 1.20(0.90, 1.50) vs 2.86(2.51, 3.21), respectively. Repeated measures ANOVA showed P<0.001, indicating a significant improvement of mucositis grading between propolis and normal saline group.

Conclusion: Propolis mouthwash is proved to be effective in reducing the severity of radiotherapyinduced mucositis in NPC patients and it is safe to be used. Therefore, its use is recommended as an adjunct treatment during the treatment protocol of NPC.

International Journal of Human and Health Sciences Supplementary Issue: 2022 Page: S41

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Published

2022-03-13

How to Cite

Hamzah, M. H., Mohamad, I., Abd Mutalib, N. S., Musa, M. Y., & Ab Hamid, S. A. (2022). Prophetic Medicine for Treatment of Radiotherapy-Induced Mucositis. International Journal of Human and Health Sciences (IJHHS), 6, S41. https://doi.org/10.31344/ijhhs.v6i0.431

Issue

2022: Supplementary Issue: 2022

Section

Poster Presentation

License

Copyright (c) 2022 Mohd Hafiz Hamzah, Irfan Mohamad, Nor Shahida Abd Mutalib, Muhamad Yusri Musa, Siti Azrin Ab Hamid

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