Study on Spectrum of Hemoglobinopathies in A Tertiary Care Hospital in Haryana, India

Kulwant Singh, - Parul, Ruchi Agarwal, Manoj Rawal, Nitika Chawla, Swaran Kaur, Parveen Rana Kundu


Background: Hemoglobinopathies are the most common inherited disorders and are major public health problem in many parts of the world. According to WHO, 5% of the world population is carrier for hemoglobinopathies. High Performance Liquid Chromatography (HPLC) is a sensitive, specific and rapid method aiding in detection of hemoglobinopathies.

Objective: To evaluate the spectrum of various hemoglobinopathies by using HPLC in a rural tertiary care hospital in Haryana, India.

Methods: This prospective study was conducted for detection of hemoglobinopathies using BioRad D-10 for patients visiting various OPDs in Bhagat Phool Singh Government Medical College for Women, Haryana, India.

Results: A total of 160 patients were included in the study. 25 (15.6%) cases were detected to have hemoglobinopathies. Most common hemoglobinopathy was beta thalassemia trait found in 9 cases (36%) followed by beta thalassemia major in 4 cases (16%), Hemoglobin D Punjab heterozygous in 3 cases (12%), Hemoglobin E heterozygous in 2 cases (8%).

Conclusion: Our study provides an overview on the spectrum of hemoglobinopathies in Haryana region of India. Hemoglobinopathies pose considerable economic and psychosocial burden on the affected individuals, society, and the country. It is concluded that HPLC is a versatile, reproducible technique for the estimation of hemoglobinopathies.

International Journal of Human and Health Sciences Vol. 08 No. 01 Jan’24 Page: 49-55


Hemoglobinopathies, high performance liquid chromatography, public health

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