Effect of Moringa oleifera Leaf Extract on High Sensitivity C-Reactive Protein, ESR And MEX SLEDAI Score in Lupus Patients

Abstract

Introduction: No definitive treatment is available for SLE. Moringa oleifera Leaf Extract is one of promising novel treatments in SLE because of anti inflammatory and immunomodulatory effect. Our study aimed to identify the effect of Moringa oleifera Leaf Extract on the level of hs-CRP, ESR and MEX SLEDAI score in lupus patients. HsCRP and ESR levels are related to the pathogenesis of SLE and they are positively correlated with the disease activity. The MEX SLEDAI score is a simple method that is quite valid for finding the degree of SLE activity, and MEX SLEDAI has the ability to evaluate clinical changes in SLE patients.

Methods: Experimental study consisted of 29 samples of SLE patients, divided into 2 groups, namely 13 SLE patients who received Moringa oleifera leaf extract as much as 40.5 mg / kg per day and 16 SLE patients who received placebo. The study was conducted for 28 days. MEX SLEDAI scores, hsCRP and ESR levels were measured before and after administration of therapy. Statistical analysis was applied using SPSS 23, with different t-test, Mann Whitney, and Will Coxon tests. P is significant if p <0.05.

Result: Result of the study showed that before Moringa oleifera leaf extract was given, the average MEX SLEDAI score was (1.56 ± 2.16) for control, and (2.69 ± 3.01) for treatment, hsCRP (0.24 ± 0.22) for control and ( 0.76 ± 1.01) for treatment, ESR (25.56 ± 23.44) for control and (26.00 ± 25.27) for treatment. There was a significant decrease in MEX SLEDAI score in the treatment group. There was no significant reduction in hsCRP and ESR of SLE patients in both groups.

Conclusion: This study showed that the effect of lowering the MEX SLEDAI score on the administration of Moringa leaf extract was significant and could not significantly reduce hsCRP and ESR levels.

International Journal of Human and Health Sciences Vol. 04 No. 04 October’20 Page : 291-297